Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysis.

ABSTRACT: The objective of the study was to identify distinct patterns in inflammatory immune responses of COVID-19 patients and to investigate their association with clinical course and outcome. Data from hospitalized COVID-19 patients were retrieved from electronic medical record. Supervised k-means clustering of serial C-reactive protein levels (CRP), absolute neutrophil counts (ANC), and absolute lymphocyte counts (ALC) was used to assign immune responses to one of three groups. Then, relationships between patterns of inflammatory responses and clinical course and outcome of COVID-19 were assessed in a discovery and validation cohort. Unbiased clustering analysis grouped 105 patients of a discovery cohort into three distinct clusters. Cluster 1 (hyper-inflammatory immune response) was characteri

SUBMITTER: Lee EE 

PROVIDER: S-EPMC8044143 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature