Modulation of gut microbiota protects against viral respiratory tract infections: a systematic review of animal and clinical studies.

ABSTRACT:

Background

Earlier studies suggest that probiotics have protective effects in the prevention of respiratory tract infections (RTIs). Whether such benefits apply to RTIs of viral origin and mechanisms supporting the effect remain unclear.

Aim

To determine the role of gut microbiota modulation on clinical and laboratory outcomes of viral RTIs.

Methods

We conducted a systematic review of articles published in Embase and MEDLINE through 20 April 2020 to identify studies reporting the effect of gut microbiota modulation on viral RTIs in clinical studies and animal models. The incidence of viral RTIs, clinical manifestations, viral load and immunological outcomes was evaluated.

Results

We included 58 studies (9 randomized controlled trials; 49 animal studies). Six of

SUBMITTER: Shi HY 

PROVIDER: S-EPMC8044287 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature