CircFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.

ABSTRACT:

Background

As a type of non-coding RNA, circular RNAs (circRNAs) are considered to be functional molecules associated with human cancers. An increasing number of circRNAs have been verified in malignant progression in a number of cancers. The circRNA, circFBXW7, has been proven to play an important role in tumor proliferation and metastasis. However, whether circFBXW7 influences progression in lung adenocarcinoma (LUAD) remains unclear.

Methods

Quantitative real-time reverse transcriptase PCR (qRT-PCR) was used to verify circFBXW7 in LUAD cell lines and LUAD tissues. Kaplan-Meier analysis was then used to compare the disease-free survival (DFS) and overall survival (OS) of these LUAD patients. The biological function of circFBXW7 was examined by overexpression and knockdown

SUBMITTER: Dong Y 

PROVIDER: S-EPMC8044477 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature