Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months.

ABSTRACT:

Purpose

Clinical characteristics and management of COVID-19 patients have evolved during the pandemic, potentially changing their outcomes. We analyzed the associations of changes in mortality rates with clinical profiles and respiratory support strategies in COVID-19 critically ill patients.

Methods

A multicenter cohort of RT-PCR-confirmed COVID-19 patients admitted at 126 Brazilian intensive care units between February 27^th and October 28^th, 2020. Assessing temporal changes in deaths, we identified distinct time periods. We evaluated the association of characteristics and respiratory support strategies with 60-day in-hospital mortality using random-effects multivariable Cox regression with inverse probability weighting.

Results

Among the 13,301

SUBMITTER: Kurtz P 

PROVIDER: S-EPMC8044656 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature