Structural brain disconnectivity mapping of post-stroke fatigue.

ABSTRACT: Stroke patients commonly suffer from post stroke fatigue (PSF). Despite a general consensus that brain perturbations constitute a precipitating event in the multifactorial etiology of PSF, the specific predictive value of conventional lesion characteristics such as size and localization remains unclear. The current study represents a novel approach to assess the neural correlates of PSF in chronic stroke patients. While previous research has focused primarily on lesion location or size, with mixed or inconclusive results, we targeted the extended structural network implicated by the lesion, and evaluated the added explanatory value of a structural disconnectivity approach with regards to the brain correlates of PSF. To this end, we estimated individual structural brain disconnectome maps i

SUBMITTER: Ulrichsen KM 

PROVIDER: S-EPMC8044723 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature