Association of Gestational Opioid Exposure and Risk of Major and Minor Congenital Malformations.

ABSTRACT:

Importance

The rapid increase of opioid-related overdoses and deaths has become a public health concern in the US. Use of prescription opioids in pregnant women has increased; results from teratogenicity studies remain controversial.

Objective

To evaluate the association between maternal prescription opioid use (excluding opioid use disorders) during pregnancy and the incidence of congenital malformations.

Design, setting, and participants

This retrospective population-based cohort study evaluated linked Rhode Island Medicaid claims and vital statistics data of live births from January 1, 2008, to December 31, 2016. Data analysis was conducted from May 1, 2019, to May 31, 2020. Women who had a live birth during the study period, but no cancer or opioid use disorder, w

SUBMITTER: Wen X 

PROVIDER: S-EPMC8044730 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature