Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of acai (Euterpe oleracea Mart.) stone in rats.

ABSTRACT: The biological and pharmacological properties of natural polyphenols of the extract of Euterpe oleracea stone (EEOS) are associated with the central nervous system (CNS). To investigate the sedative and myorelaxant activity of EEOS in vivo, this study aimed to present the myorelaxant and sedative effects of EEOS in Wistar rats using spontaneous locomotor activity and motor electrophysiology. A total of 108 animals were used in the following experiments: a) behavioral tests (n = 27); b) electromyographic recordings of skeletal muscle (n = 27); c) respiratory muscle activity recordings (n = 27); d) cardiac muscle activity recordings (n = 27). The behavioral characteristics were measured according to the latency time of onset, the transient loss of posture reflex and maximum mus

SUBMITTER: Muto NA 

PROVIDER: S-EPMC8044785 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature