Antigenic Challenge Influences Epigenetic Changes in Antigen-Specific T Regulatory Cells.

ABSTRACT:

Background

Human regulatory T cells (Tregs) are the fundamental component of the immune system imposing immune tolerance via control of effector T cells (Teffs). Ongoing attempts to improve Tregs function have led to the creation of a protocol that produces antigen-specific Tregs, when polyclonal Tregs are stimulated with monocytes loaded with antigens specific for type 1 diabetes. Nevertheless, the efficiency of the suppression exerted by the produced Tregs depended on the antigen with the best results when insulin β chain peptide 9-23 was used. Here, we examined epigenetic modifications, which could influence these functional differences.

Methods

The analysis was pefromed in the sorted specific (SPEC, proliferating) and unspecific (UNSPEC, non-proliferating) subsets

SUBMITTER: Iwaszkiewicz-Grzes D 

PROVIDER: S-EPMC8044853 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature