Analysis of radiotherapy-induced alteration of CD8⁺ T cells and PD-L1 expression in patients with uterine cervical squamous cell carcinoma.

ABSTRACT: Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse the alteration of CD8⁺ T-cell infiltration and programmed death-ligand 1 (PD-L1) expression following radiotherapy in clinical samples from patients with uterine cervical squamous cell carcinoma. Additionally, the current study sought to analyse the association between these immune responses and clinical outcomes. A total of 75 patients who received either definitive chemoradiotherapy or radiotherapy were retrospectively analyzed. CD8⁺ T-cell infiltration and PD-L1 expression were determined by immunohistochemistry using biopsy specimens before radiotherapy (pre-RT) and after 10 Gy radiotherapy (post-10 Gy). The PD-L1⁺

SUBMITTER: Mori Y 

PROVIDER: S-EPMC8045163 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature