Structural Characterization of Sulfated Glycosaminoglycans Using Charge-Transfer Dissociation.

ABSTRACT: Glycosaminoglycans (GAGs) participate in a broad range of physiological processes, and their structures are of interest to researchers in structural biology and medicine. Although they are abundant in tissues and extracellular matrices, their structural heterogeneity makes them challenging analytes. Mass spectrometry, and more specifically, tandem mass spectrometry, is particularly well suited for their analysis. Many tandem mass spectrometry techniques have been examined for their suitability toward the structural characterization of GAGs. Threshold activation methods such as collision-induced dissociation (CID) produce mainly glycosidic cleavages and do not yield a broad range of structurally informative cross-ring fragments. Considerable research efforts have been directed at finding ot

SUBMITTER: Pepi LE 

PROVIDER: S-EPMC8045215 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature