Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.

ABSTRACT:

Background

Multiple factors have been attributed to acne vulgaris predisposition and individual variations in the severity of skin symptoms, and genetics stood out as one of the major factors.

Methods

We performed a systematic review on the genes and their variants that have been investigated for association with acne presentation and severity. A random-effect meta-analysis using the allele model (minor allele vs. major allele) was also conducted to provide an overall estimation of risk effects of frequently reported gene variants. This included a subset data of 982 acne cases and 846 controls extracted from our existing GWAS database on various allergic and skin diseases among Singapore Chinese.

Results

Systematic review of 51 articles covering Asians and Caucasians

SUBMITTER: Heng AHS 

PROVIDER: S-EPMC8045239 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature