Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types.

ABSTRACT: N6-Methyladenosine (m6A) is an RNA modification that interacts with numerous coding and non-coding RNAs and plays important roles in the development of cancers. Nonetheless, the clinical impacts of m6A interactive genes on these cancers largely remain unclear since most studies focus only on a single cancer type. We comprehensively evaluated m6A modification patterns, including 23 m6A regulators and 83 interactive coding and non-coding RNAs among 9,804 pan-cancer samples. We used clustering analysis to identify m6A subtypes and constructed the m6A signature based on an unsupervised approach. We used the signatures to identify potential m6A modification targets across the genome. The prognostic value of one target was further validated in 3,444 samples from six external datasets. We develop

SUBMITTER: Shen S 

PROVIDER: S-EPMC8045265 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature