Heritability of DNA methylation in threespine stickleback (Gasterosteus aculeatus).

ABSTRACT: Epigenetic mechanisms underlying phenotypic change are hypothesized to contribute to population persistence and adaptation in the face of environmental change. To date, few studies have explored the heritability of intergenerationally stable methylation levels in natural populations, and little is known about the relative contribution of cis- and trans-regulatory changes to methylation variation. Here, we explore the heritability of DNA methylation, and conduct methylation quantitative trait loci (meQTLs) analysis to investigate the genetic architecture underlying methylation variation between marine and freshwater ecotypes of threespine stickleback (Gasterosteus aculeatus). We quantitatively measured genome-wide DNA methylation in fin tissue using reduced representation bisulfite sequenci

SUBMITTER: Hu J 

PROVIDER: S-EPMC8045681 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature