Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks.

ABSTRACT: Sex and sexual differentiation are pervasive across the tree of life. Because females and males often have substantially different functional requirements, we expect selection to differ between the sexes. Recent studies in diverse species, including humans, suggest that sexually antagonistic viability selection creates allele frequency differences between the sexes at many different loci. However, theory and population-level simulations indicate that sex-specific differences in viability would need to be very large to produce and maintain reported levels of between-sex allelic differentiation. We address this contradiction between theoretical predictions and empirical observations by evaluating evidence for sexually antagonistic viability selection on autosomal loci in humans using the lar

SUBMITTER: Kasimatis KR 

PROVIDER: S-EPMC8045711 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature