Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies.

ABSTRACT:

Background

Survival among children with high-risk solid tumors remains poor. Reprogrammed metabolism promotes tumor growth and may contain therapeutic liabilities. Tumor metabolism has been assessed in adults using intra-operative ¹³C-glucose infusions. Pediatric tumors differ from adult cancers in their low mutational burden and derivation from embryonic tissues. Here we used ¹³C infusions to examine tumor metabolism in children, comparing phenotypes among tumor types and between childhood and adult cancers.

Methods

Patients recruited to study NCT03686566 received an intra-operative infusion of [U-¹³C]glucose during tumor resection to evaluate central carbon pathways in the tumor, with concurrent metabolomics to provide a broad overview of m

SUBMITTER: Johnston K 

PROVIDER: S-EPMC8045768 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature