Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging.

ABSTRACT: Aging drives progressive loss of the ability of tissues to recover from stress, partly through loss of somatic stem cell function and increased senescent burden. We demonstrate that bone marrow-derived mesenchymal stem cells (BM-MSCs) rapidly senescence and become dysfunctional in culture. Injection of BM-MSCs from young mice prolonged life span and health span, and conditioned media (CM) from young BM-MSCs rescued the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM-MSC CM extended life span of Ercc1^-/- mice similarly to injection of young BM-MSCs. Finally, treatment with EVs from MSCs generated from human ES cells reduced senescence in culture and in vivo, and improved health span. Thus, MSC EVs represent an effective and safe a

SUBMITTER: Dorronsoro A 

PROVIDER: S-EPMC8045949 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature