Abnormal dynamic functional connectivity is linked to recovery after acute ischemic stroke.

ABSTRACT: The aim of the current study was to explore the whole-brain dynamic functional connectivity patterns in acute ischemic stroke (AIS) patients and their relation to short and long-term stroke severity. We investigated resting-state functional MRI-based dynamic functional connectivity of 41 AIS patients two to five days after symptom onset. Re-occurring dynamic connectivity configurations were obtained using a sliding window approach and k-means clustering. We evaluated differences in dynamic patterns between three NIHSS-stroke severity defined groups (mildly, moderately, and severely affected patients). Furthermore, we built Bayesian hierarchical models to evaluate the predictive capacity of dynamic connectivity and examine the interrelation with clinical measures, such as white matter hyper

SUBMITTER: Bonkhoff AK 

PROVIDER: S-EPMC8046120 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature