Structural control energy of resting-state functional brain states reveals less cost-effective brain dynamics in psychosis vulnerability.

ABSTRACT: How the brain's white-matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder with an extremely high risk for psychosis providing a test case to study developmental aspects of schizophrenia. In this study, we used principles from network control theory to probe the implications of aberrant structural connectivity for the brain's functional dynamics in 22q11DS. We retrieved brain states from resting-state functional magnetic resonance images of 78 patients with 22q11DS and 85 healthy controls. Then, we compared them in terms of persistence control energy; that is, the control energy that would be required to p

SUBMITTER: Zoller D 

PROVIDER: S-EPMC8046160 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature