Validation of risk scores for ischaemic stroke in atrial fibrillation across the spectrum of kidney function.

ABSTRACT:

Aims

The increasing prevalence of ischaemic stroke (IS) can partly be explained by the likewise growing number of patients with chronic kidney disease (CKD). Risk scores have been developed to identify high-risk patients, allowing for personalized anticoagulation therapy. However, predictive performance in CKD is unclear. The aim of this study is to validate six commonly used risk scores for IS in atrial fibrillation (AF) patients across the spectrum of kidney function.

Methods and results

Overall, 36 004 subjects with newly diagnosed AF from SCREAM (Stockholm CREAtinine Measurements), a healthcare utilization cohort of Stockholm residents, were included. Predictive performance of the AFI, CHADS2, Modified CHADS2, CHA2DS2-VASc, ATRIA, and GARFIELD-AF risk scores was evaluate

SUBMITTER: de Jong Y 

PROVIDER: S-EPMC8046502 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature