NASH limits anti-tumour surveillance in immunotherapy-treated HCC.

ABSTRACT: Hepatocellular carcinoma (HCC) can have viral or non-viral causes^1-5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal response to therapy is an unmet need^6,7. Here we report the progressive accumulation of exhausted, unconventionally activated CD8⁺PD1⁺ T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, therapeutic immunotherapy targeted at programmed death-1 (PD1) expanded activated CD8⁺PD1⁺ T cells within tumours but did not lead to tumour regression, which indicates that tumour immune surveillance was impaired. When given prophylactically, anti-PD1 treatment led to an inc

SUBMITTER: Pfister D 

PROVIDER: S-EPMC8046670 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature