Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains.

ABSTRACT:

Background

Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted.

Objectives

To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls.

Methods

Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm² ) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number.

Results

Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleu

SUBMITTER: Hartstone WG 

PROVIDER: S-EPMC8046734 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature