Regulator of G protein signaling 17 represents a novel target for treating cisplatin induced hearing loss.

ABSTRACT: Regulators of G protein signaling (RGS) accelerate the GTPase activity of G proteins to enable rapid termination of the signals triggered by G protein-coupled receptors (GPCRs). Activation of several GPCRs, including cannabinoid receptor 2 (CB2R) and adenosine A₁ receptor (A₁AR), protects against noise and drug-induced ototoxicity. One such drug, cisplatin, an anticancer agent used to treat various solid tumors, produces permanent hearing loss in experimental animals and in a high percentage of cancer patients who undergo treatments. In this study we show that cisplatin induces the expression of the RGS17 gene and increases the levels of RGS17 protein which contributes to a significant proportion of the hearing loss. Knockdown of RGS17 suppressed cisplatin-induced hea

SUBMITTER: Dhukhwa A 

PROVIDER: S-EPMC8046767 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature