Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis.

ABSTRACT: Elevations in peripheral inflammatory markers have been reported in patients with psychosis. Whether this represents an inflammatory process defined by individual or subgroups of markers is unclear. Further, relationships between peripheral inflammatory marker elevations and brain structure, cognition, and clinical features of psychosis remain unclear. We hypothesized that a pattern of plasma inflammatory markers, and an inflammatory subtype established from this pattern, would be elevated across the psychosis spectrum and associated with cognition and brain structural alterations. Clinically stable psychosis probands (Schizophrenia spectrum, n = 79; Psychotic Bipolar disorder, n = 61) and matched healthy controls (HC, n = 60) were assessed for 15 peripheral inflammatory markers, cortical

SUBMITTER: Lizano P 

PROVIDER: S-EPMC8046847 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature