Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth.

ABSTRACT: Recent evidence suggests increased metabolic and physiologic aging rates in premature-born adults. While the lasting consequences of premature birth on human brain development are known, its impact on brain aging remains unclear. We addressed the question of whether premature birth impacts brain age gap estimates (BrainAGE) using an accurate and robust machine-learning framework based on structural MRI in a large cohort of young premature-born adults (n = 101) and full-term (FT) controls (n = 111). Study participants are part of a geographically defined population study of premature-born individuals, which have been followed longitudinally from birth until young adulthood. We investigated the association between BrainAGE scores and perinatal variables as well as with outcomes

SUBMITTER: Hedderich DM 

PROVIDER: S-EPMC8047054 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature