Autophagy-Related Long Non-coding RNA Signature as Indicators for the Prognosis of Uveal Melanoma.

ABSTRACT: This study aimed to develop an autophagy-associated long non-coding RNA (lncRNA) signature to predict the prognostic outcomes of uveal melanoma (UM). The data of UM from The Cancer Genome Atlas (TCGA) were enrolled to obtain differentially expressed genes (DEGs) between metastasizing and non-metastasizing UM patients. A total of 13 differentially expressed autophagy genes were identified and validated in Gene Expression Omnibus, and 11 autophagy-related lncRNAs were found to be associated with overall survival. Through performing least absolute shrinkage and selection operator regression analyses, a six-autophagy-related lncRNA signature was built, and its efficacy was confirmed by receiver-operating characteristic, Kaplan-Meier analysis, and univariate and multivariate Cox regression anal

SUBMITTER: Cui Y 

PROVIDER: S-EPMC8047156 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature