Robust induction of T_RMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses.

ABSTRACT: Antigen-specific lung-resident memory T cells (T_RMs) constitute the first line of defense that mediates rapid protection against respiratory pathogens and inspires novel vaccine designs against infectious pandemic threats, yet effective means of inducing T_RMs, particularly via non-viral vectors, remain challenging. Here, we demonstrate safe and potent induction of lung-resident T_RMs using a biodegradable polymeric nanoshell that co-encapsulates antigenic peptides and TLR9 agonist CpG-oligodeoxynucleotide (CpG-ODN) in a virus-mimicking structure. Through subcutaneous priming and intranasal boosting, the combinatorial nanoshell vaccine elicits prominent lung-resident CD4⁺ and CD8⁺ T cells that surprisingly show better durability than liv

SUBMITTER: Lin PH 

PROVIDER: S-EPMC8047433 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature