A circular network of coregulated sphingolipids dictates lung cancer growth and progression.

ABSTRACT:

Background

Sphingolipid metabolism is among the top dysregulated pathways in non-small cell lung carcinomas (NSCLC). However, the molecular control of sphingolipid metabolic reprogramming in cancer progression remains unclear.

Methods

We first determined the correlation between sphingolipid metabolic gene expression and patient prognosis. We then carried out sphingolipidomics analysis of health individual and NSCLC patient sera as well as B3GNT5 and GAL3ST1 genetically perturbed NSCLC cell lines. We used these cell lines to perform tumorigenesis study to determine the cellular role of B3GNT5 and GAL3ST1 in cancer growth and progression.

Findings

The expression of B3GNT5 and GAL3ST1 among sphingolipid metabolic enzymes is most significantly associated with patient prog

SUBMITTER: Meng Q 

PROVIDER: S-EPMC8047482 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature