Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine.

ABSTRACT:

Background

Diarrheal diseases are a leading cause of global morbidity and mortality affecting all ages, but especially children under the age of five in resource-limited settings. Shigella is a leading contributor to diarrheal diseases caused by bacterial pathogens and is considered a significant antimicrobial resistance threat. While improvements in hygiene, and access to clean water help as control measures, vaccination remains one of the most viable options for significantly reducing morbidity and mortality.

Methods

Flexyn2a is a bioconjugate vaccine manufactured using novel conjugation methodologies enzymatically linking the O-polysaccharide of S. flexneri 2a to exotoxin A of Pseudomonas aeruginosa. The protective capacity of Flexyn2a was assessed in a controlled human i

SUBMITTER: Clarkson KA 

PROVIDER: S-EPMC8047506 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature