STING and cGAS gene expressions were downregulated among HIV-1-infected persons after antiretroviral therapy.

ABSTRACT:

Background

The HIV-1 epidemic is still considered a global public health problem, but great advances have been made in fighting it by antiretroviral therapy (ART). ART has a considerable impact on viral replication and host immunity. The production of type I interferon (IFN) is key to the innate immune response to viral infections. The STING and cGAS proteins have proven roles in the antiviral cascade. The present study aimed to evaluate the impact of ART on innate immunity, which was represented by STING and cGAS gene expression and plasma IFN-α level.

Methods

This cohort study evaluated a group of 33 individuals who were initially naïve to therapy and who were treated at a reference center and reassessed 12 months after starting ART. Gene expression levels and viral load w

SUBMITTER: de Lima LLP 

PROVIDER: S-EPMC8047565 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature