Clinical metagenomics assessments improve diagnosis and outcomes in community-acquired pneumonia.

ABSTRACT:

Background

Identifying the causes of community-acquired pneumonia (CAP) is challenging due to the disease's complex etiology and the limitations of traditional microbiological diagnostic methods. Recent advances in next generation sequencing (NGS)-based metagenomics allow pan-pathogen detection in a single assay, and may have significant advantages over culture-based techniques.

Results

We conducted a cohort study of 159 CAP patients to assess the diagnostic performance of a clinical metagenomics assay and its impact on clinical management and patient outcomes. When compared to other techniques, clinical metagenomics detected more pathogens in more CAP cases, and identified a substantial number of polymicrobial infections. Moreover, metagenomics results led to changes in or

SUBMITTER: Xie F 

PROVIDER: S-EPMC8047593 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature