Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins.

ABSTRACT: The re-emergence of Chikungunya virus (CHIKV) infection in humans with no approved antiviral therapies or vaccines is one of the major problems with global significance. In the present investigation, we screened 80 in-house quinoline derivatives for their anti-CHIKV activity by computational techniques and found 4-hydroxy-1-methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) to have potential binding affinities with CHIKV nsP2 and E2 glycoproteins. QVIR was evaluated in vitro for its anti-CHIKV potential. QVIR showed strong inhibition of CHIKV infection with an EC₅₀ (50% effective concentration) value of 2.2 ± 0.49 μM without significant cytotoxicity (CC₅₀ > 200 μM) and was chosen for further elucidation of its antiviral mechanism. The infectious

SUBMITTER: Islamuddin M 

PROVIDER: S-EPMC8047676 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature