Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption.

ABSTRACT: Bidirectional communication between cells and their surrounding environment is critical in both normal and pathological settings. Extracellular vesicles (EVs), which facilitate the horizontal transfer of molecules between cells, are recognized as an important constituent of cell-cell communication. In cancer, alterations in EV secretion contribute to the growth and metastasis of tumor cells. However, the mechanisms underlying these changes remain largely unknown. Here, we show that centrosome amplification is associated with and sufficient to promote small extracellular vesicle (_SEV) secretion in pancreatic cancer cells. This is a direct result of lysosomal dysfunction, caused by increased reactive oxygen species (ROS) downstream of extra centrosomes. We propose that defects in

SUBMITTER: Adams SD 

PROVIDER: S-EPMC8047808 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature