Excess deaths in treatment-resistant depression.

ABSTRACT:

Background

Patients with treatment-resistant depression (TRD) have an increased mortality risk compared with other patients with depression, but it is not known how this translates into absolute numbers of excess deaths.

Methods

Swedish national registers were used to identify a cohort of 118,774 antidepressant initiators 18-69 years old with a depression diagnosis. Patients who initiated a third consecutive treatment trial were classified as having TRD. Flexible parametric survival models were used to estimate the mortality risk due to all causes and external causes (suicides and accidents), comparing TRD patients with patients with other depression while adjusting for clinical and sociodemographic covariates and including interactions with TRD, age, and Charlson comorbidit

SUBMITTER: Brenner P 

PROVIDER: S-EPMC8047832 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature