Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two-step process.

ABSTRACT:

Rationale

Paper spray offers a rapid screening test without the need for sample preparation. The incomplete extraction of paper spray allows for further testing using more robust, selective and sensitive techniques such as liquid chromatography/mass spectrometry (LC/MS). Here we develop a two-step process of paper spray followed by LC/MS to (1) rapidly screen a large number of samples and (2) confirm any disputed results. This demonstrates the applicability for testing medication adherence from a fingerprint.

Methods

Following paper spray analysis, drugs of abuse samples were analysed using LC/MS. All analyses were completed using a Q Exactive™ Plus Orbitrap™ mass spectrometer. This two-step procedure was applied to fingerprints collected from patients on a maintained dose o

SUBMITTER: Costa C 

PROVIDER: S-EPMC8047880 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature