Association of glycemia with insulin sensitivity and β-cell function in adults with early type 2 diabetes on metformin alone.

ABSTRACT:

Aims

Evaluate the relationship between measures of glycemia with β-cell function and insulin sensitivity in adults with early type 2 diabetes mellitus (T2DM).

Methods

This cross-sectional analysis evaluated baseline data from 3108 adults with T2DM <10 years treated with metformin alone enrolled in the Glycemia Reduction Approaches in Diabetes. A Comparative Effectiveness (GRADE) Study. Insulin and C-peptide responses and insulin sensitivity were calculated from 2-h oral glucose tolerance tests. Regression models evaluated the relationships between glycemic measures (HbA1c, fasting and 2-h glucose), measures of β-cell function and insulin sensitivity.

Results

Insulin and C-peptide responses were inversely associated with insulin sensitivity. Glycemic measures were inve

SUBMITTER: Utzschneider KM 

PROVIDER: S-EPMC8048071 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature