Differentiation of brain metastases from small and non-small lung cancers using apparent diffusion coefficient (ADC) maps.

ABSTRACT:

Background

Brain metastases are particularly common in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with NSCLC showing a less  aggressive clinical course and lower chemo- and radio sensitivity compared to SCLC. Early adequate therapy is highly desirable and depends on a reliable classification of tumor type. The apparent diffusion coefficient is a noninvasive neuroimaging marker with the potential to differentiate between major histological subtypes. Here we determine the sensitivity and specificity of the apparent diffusion coefficient to distinguish between NSCLC and SCLC.

Methods

We enrolled all NSCLC and SCLC patients diagnosed between 2008 and 2019 at the University Medical Center Göttingen. Cranial MR scans were visually inspected

SUBMITTER: Muller SJ 

PROVIDER: S-EPMC8048287 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature