Improvement of hepatocyte engraftment by co-transplantation with pancreatic islets in hepatocyte transplantation.

ABSTRACT: Because of the fragility of isolated hepatocytes, extremely poor engraftment of transplanted hepatocytes remains a severe issue in hepatocyte transplantation. Therefore, improving hepatocyte engraftment is necessary to establish hepatocyte transplantation as a standard therapy. Since the pancreatic islets are known to have favorable autocrine effects, we hypothesized that the transplanted islets might influence not only the islets but also the nearby hepatocytes, subsequently promoting engraftment. We evaluated the effects of islet co-transplantation using an analbuminemic rat model (in vivo model). Furthermore, we established a mimicking in vitro model to investigate the underlying mechanisms. In an in vivo model, the hepatocyte engraftment was significantly improved only when the islets

SUBMITTER: Saitoh Y 

PROVIDER: S-EPMC8048420 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature