Brain Microglial Activation Increased in Glucocerebrosidase (GBA) Mutation Carriers without Parkinson's disease.

ABSTRACT:

Background

Glucocerebrosidase gene mutations are a common genetic risk factor for Parkinson's disease. They exhibit incomplete penetrance. The objective of the present study was to measure microglial activation and dopamine integrity in glucocerebrosidase gene mutation carriers without Parkinson's disease compared to controls.

Methods

We performed PET scans on 9 glucocerebrosidase gene mutation carriers without Parkinson's disease and 29 age-matched controls. We measured microglial activation as ¹¹ C-(R)-PK11195 binding potentials, and dopamine terminal integrity with ¹⁸ F-dopa influx constants.

Results

The ¹¹ C-(R)-PK11195 binding potential was increased in the substantia nigra of glucocerebrosidase gene carriers compared with control

SUBMITTER: Mullin S 

PROVIDER: S-EPMC8048428 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature