Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden.

ABSTRACT: With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Swedish registers. Five children without parental CNS tumor were matched randomly to generate the population comparisons. Relative risk (RR) and absolute excess risk (AER) were calculated for overall somatic diseases, and hazard ratio (HR) was calculated for specific type of somatic diseases. A total of 2231 somatic disease diagnoses were identified in children of survivors with a cumulative incidence

SUBMITTER: Huang W 

PROVIDER: S-EPMC8048456 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature