Biological stratification of clinical disease courses in childhood immune thrombocytopenia.

ABSTRACT:

Background

In childhood immune thrombocytopenia (ITP), an autoimmune bleeding disorder, there is a need for better prediction of individual disease courses and treatment outcomes.

Objective

To predict the response to intravenous immunoglobulins (IVIg) and ITP disease course using genetic and immune markers.

Methods

Children aged younger than 7 years with newly diagnosed ITP (N = 147) from the Treatment With or Without IVIG for Kids with ITP study were included, which randomized children to an IVIg or observation group. A total of 46 variables were available: clinical characteristics, targeted genotyping, lymphocyte immune phenotyping, and platelet autoantibodies.

Results

In the treatment arm, 48/80 children (60%) showed a complete response (platelets ≥100 × 10<

SUBMITTER: Schmidt DE 

PROVIDER: S-EPMC8048469 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature