Antibodies Contributing to Focal Epilepsy Signs and Symptoms Score.

ABSTRACT:

Objective

Diagnosing autoimmune encephalitis (AIE) is difficult in patients with less fulminant diseases such as epilepsy. However, recognition is important, as patients require immunotherapy. This study aims to identify antibodies in patients with focal epilepsy of unknown etiology, and to create a score to preselect patients requiring testing.

Methods

In this prospective, multicenter cohort study, adults with focal epilepsy of unknown etiology, without recognized AIE, were included, between December 2014 and December 2017, and followed for 1 year. Serum, and if available cerebrospinal fluid, were analyzed using different laboratory techniques. The ACES score was created using factors favoring an autoimmune etiology of seizures (AES), as determined by multivariate logistic

SUBMITTER: de Bruijn MAAM 

PROVIDER: S-EPMC8048471 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature