Multi-tissue transcriptome-wide association studies.

ABSTRACT: A transcriptome-wide association study (TWAS) attempts to identify disease associated genes by imputing gene expression into a genome-wide association study (GWAS) using an expression quantitative trait loci (eQTL) data set and then testing for associations with a trait of interest. Regulatory processes may be shared across related tissues and one natural extension of TWAS is harnessing cross-tissue correlation in gene expression to improve prediction accuracy. Here, we studied multi-tissue extensions of lasso regression and random forests (RF), joint lasso and RF-MTL (multi-task learning RF), respectively. We found that, on our chosen eQTL data set, multi-tissue methods were generally more accurate than their single-tissue counterparts, with RF-MTL performing the best. Simulations showed

SUBMITTER: Grinberg NF 

PROVIDER: S-EPMC8048510 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature