Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis.

ABSTRACT:

Background

A prolonged prothrombin time (PT) is a common feature in sepsis indicating consumptive coagulopathy.

Objectives

To determine the association between a prolonged PT and aberrations in other host response mechanisms in sepsis.

Methods

Patients admitted to the intensive care unit with sepsis were divided in quartiles according to the highest PT value measured within 24 h after admission. The host response was evaluated by measuring 19 plasma biomarkers reflecting pathways implicated in sepsis pathogenesis and by blood leukocyte gene expression profiling.

Measurements and main results

Of 1524 admissions for sepsis, 386 (25.3%) involved patients with a normal PT (≤12.7 s); the remaining quartiles entailed 379 (24.9%) patients with a slightly prolonged PT

SUBMITTER: van Vught LA 

PROVIDER: S-EPMC8048632 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature