Neurobiological predictors for clinical trajectories in fully remitted depressed patients.

ABSTRACT:

Background

Serious long term health and economic detriment accompany residual depressive symptoms even in fully remitted depressed patients (rMDD). Neurobiological predictors for rMDD patients' illness trajectory are absent.

Methods

rMDD patients (n = 39, female = 26) underwent magnetic resonance imaging. Baseline analyses of brain structure via voxel-based morphometry and brain function via functional connectivity (FC) at rest were correlated with changes in the Hamilton Depression Rating Scale between baseline and follow-up, and incidence of a recurrent major depressive episode (MDE) within a 2-year period.

Results

Gray matter increases in default mode (DN) regions in the posterior cingulate cortex (PCC) and increased resting-state FC within the DN both predicted ch

SUBMITTER: Blank TS 

PROVIDER: S-EPMC8048641 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature