A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT.

ABSTRACT:

Introduction

Counteracting impaired brain glucose metabolism with ketones may improve cognition in mild cognitive impairment (MCI).

Methods

Cognition, plasma ketone response, and metabolic profile were assessed before and 6 months after supplementation with a ketogenic drink containing medium chain triglyceride (ketogenic medium chain triglyceride [kMCT]; 15 g twice/day; n = 39) or placebo (n = 44).

Results

Free and cued recall (Trial 1; P = .047), verbal fluency (categories; P = .024), Boston Naming Test (total correct answers; P = .033), and the Trail-Making Test (total errors; P = .017) improved significantly in the kMCT group compared to placebo (analysis of covariance; pre-intervention score, sex, age, education, and apolipoprotein E4 as covariates). Some cogniti

SUBMITTER: Fortier M 

PROVIDER: S-EPMC8048678 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature