Membranous nephropathy: current understanding of various causes in light of new target antigens.

ABSTRACT:

Purpose of review

Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass spectrometry of solubilized digested proteins, several antigens associated with various causes have been described in patients with membranous nephropathy. The purpose of this review is to report on those "new" antigens and to analyse the clinicopathological correlations that make each of this antigen unique.

Recent findings

This article covers the literature of the last 2 years devoted to the description of those new antigens and biomarkers including NELL-1 an

SUBMITTER: Ronco P 

PROVIDER: S-EPMC8048721 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature