Kinetics of Muscle Carnosine Decay after β-Alanine Supplementation: A 16-wk Washout Study.

ABSTRACT:

Purpose

This study aimed to describe the kinetics of carnosine washout in human skeletal muscle over 16 wk.

Methods

Carnosine washout kinetics were studied in 15 young, physically active omnivorous men randomly assigned to take 6.4 g·d-1 of β-alanine (n = 11) or placebo (n = 4) for 8 wk. Muscle carnosine content (M-Carn) was determined before (PRE), immediately after (POST), and 4, 8, 12, and 16 wk after supplementation. High-intensity exercise tests were performed at these same time points. Linear and exponential models were fitted to the washout data, and the leave-one-out method was used to select the model with the best fit for M-Carn decay data. Repeated-measures correlation analysis was used to assess the association between changes in M-Carn and changes in performance

SUBMITTER: Yamaguchi GC 

PROVIDER: S-EPMC8048732 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature