The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis.

ABSTRACT:

Background

The prevalence of fungal disease in cystic fibrosis (CF) and non-CF bronchiectasis is increasing and the clinical spectrum is widening. Poor sensitivity and a lack of standard diagnostic criteria renders interpretation of culture results challenging. In order to develop effective management strategies, a more accurate and comprehensive understanding of the airways fungal microbiome is required. The study aimed to use DNA sequences from sputum to assess the load and diversity of fungi in adults with CF and non-CF bronchiectasis.

Methods

Next generation sequencing of the ITS2 region was used to examine fungal community composition (n = 176) by disease and underlying clinical subgroups including allergic bronchopulmonary aspergillosis, chronic necrotizing pulmonary a

SUBMITTER: Cuthbertson L 

PROVIDER: S-EPMC8048771 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature