Dataset Information

Fluorescent and Water Dispersible Single-Chain Nanoparticles: Core-Shell Structured Compartmentation.

ABSTRACT: Single-chain nanoparticles (SCNPs) are highly versatile structures resembling proteins, able to function as catalysts or biomedical delivery systems. Based on their synthesis by single-chain collapse into nanoparticular systems, their internal structure is complex, resulting in nanosized domains preformed during the crosslinking process. In this study we present proof of such nanocompartments within SCNPs via a combination of electron paramagnetic resonance (EPR) and fluorescence spectroscopy. A novel strategy to encapsulate labels within these water dispersible SCNPs with hydrodynamic radii of ≈5 nm is presented, based on amphiphilic polymers with additional covalently bound labels, attached via the copper catalyzed azide/alkyne "click" reaction (CuAAC). A detailed profile of the interior of the SCNPs and the labels' microenvironment was obtained via electron paramagnetic resonance (EPR) experiments, followed by an assessment of their photophysical properties.

SUBMITTER: Hoffmann JF

PROVIDER: S-EPMC8048794 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Fluorescent and Water Dispersible Single-Chain Nanoparticles: Core-Shell Structured Compartmentation.

Hoffmann Justus F JF Roos Andreas H AH Schmitt Franz-Josef FJ Hinderberger Dariush D Binder Wolfgang H WH

Angewandte Chemie (International ed. in English) 20210225 14

Single-chain nanoparticles (SCNPs) are highly versatile structures resembling proteins, able to function as catalysts or biomedical delivery systems. Based on their synthesis by single-chain collapse into nanoparticular systems, their internal structure is complex, resulting in nanosized domains preformed during the crosslinking process. In this study we present proof of such nanocompartments within SCNPs via a combination of electron paramagnetic resonance (EPR) and fluorescence spectroscopy. A ...[more]

PMID: 33373475

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Project description:Gold nanoparticles (Au NPs) with graphene oxide (GO) shell (Au@GO), silver nanoparticles (Ag NPs) with GO shell (Ag@GO), and gold silver nanoparticles (AuAgNPs) with GO shell (AuAg@GO) were synthesized employing a cationic surfactant. The prepared core@shell structures were used for in situ synthesis of long tubular polyaniline structures employing cetyl trimethyl ammonium bromide (CTAB) as a soft template. This process led to a notable enhancement in the tubular nanostructure of PANI, extending its length beyond 10 μm, in the case of using core/shell Au@GO, Ag@GO, and AuAg@GO structures. To evaluate their applicability and compatibility, the dispersibility of these nanocomposites was assessed in three distinct solvents: water, dimethyl sulfoxide (DMSO), and N-Methyl-2-pyrrolidone (NMP). Subsequently, the dedoping of PANI within the prepared nanocomposites was scrutinized using UV-Visible (UV-Vis) spectroscopy, which revealed a reduction in the I750/I315 ratio from 1.00 to 0.66 when subjected to water and NMP solvents, respectively. Notably, the dedoping of the AuAg@GO/PANI nanocomposite was predominantly observed in NMP, attributable to the presence of hydrogen bonding interactions and the basic properties of NMP. In terms of ionic conductivity, it was observed that the prepared nanocomposite exhibited its highest conductivity in a water-based medium, registering at 1982 μs. Furthermore, the AuAg@GO/PANI nanocomposite exhibited superior sensing capabilities in comparison to PANI-based gas sensor devices, particularly when exposed to acetone, CO2, NO2, and H2S. Remarkably, at room temperature (25 °C), the AuAg@GO/PANI nanocomposite displayed rapid response and recovery times, with values of 279 s, 431 s, 335 s, and 509 s for 1 ppm concentrations of CO2, NO2, H2S, and acetone, respectively. The sensitivity of these sensors towards acetone, CO2, NO2, and H2S, was quantified by analyzing the slope of the response versus the target gas concentration, revealing the AuAg@GO/PANI nanocomposite to exhibit the highest sensitivity, particularly towards NO2.

Dataset Information

Fluorescent and Water Dispersible Single-Chain Nanoparticles: Core-Shell Structured Compartmentation.

Publications

Fluorescent and Water Dispersible Single-Chain Nanoparticles: Core-Shell Structured Compartmentation.

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