Levodopa Versus Dopamine Agonist after Subthalamic Stimulation in Parkinson's Disease.

ABSTRACT:

Background

No clinical trials have been specifically designed to compare medical treatments after surgery in Parkinson's disease (PD).

Objective

Study's objective was to compare the efficacy and safety of levodopa versus dopamine agonist monotherapy after deep brain stimulation (DBS) in PD.

Methods

Thirty-five surgical candidates were randomly assigned to receive postoperative monotherapy with either levodopa or dopamine agonist in a randomized, single-blind study. All patients were reevaluated in short- (3 months), mid- (6 months), and long-term (2.5 years) follow-up after surgery. The primary outcome measure was the change in the Non-Motor Symptoms Scale (NMSS) 3 months after surgery. Secondary outcome measures were the percentage of patients maintaining monotherapy

SUBMITTER: Picillo M 

PROVIDER: S-EPMC8048876 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature